BBC News ... Aug 31, 2000 Anti-aging research might one-day lead to a fitter and longer retirement. For the first time, scientists have succeeded in boosting an animal's life span with drugs. Microscopic worms given the therapy lived nearly 50% longer than normal. The researchers say the experiments are the first real indication that aging can be treated. Clinical trials for disorders such as Alzheimer's disease and Parkinson's could take place in the near future. "As far as we know, this is the first convincing example of drugs being used to extend life span," said Dr Gordon Lithgow of the University of Manchester, UK, who carried out the research along with colleagues in the United States. He said the drugs had an anti-ageing effect on the worms. "The treated worms appear youthful and active at the same time as when the untreated worms are showing the characteristics of old age," he told BBC News Online. The nematode worm, Caenorhabditis elegans, has been studied in the laboratory for many years. Around 40% of the worm's genes are also found in humans. The scientists added a cocktail of two synthetic drugs to the medium in which the worms, when kept in the laboratory, live and reproduce. Both of the drugs are antioxidants. They mimic the effect of natural enzymes that mop up free radicals - highly reactive molecules that damage cells. When given the drugs, the worms lived on average nearly 50% longer than normal. The reason, the scientists believe, is that the drugs prevented free radical damage. "The idea that antioxidants might have an effect [on aging] has been around for quite a long time," said Professor David White, director of science at the Biotechnology and Biological Sciences Research Council, UK, which is funding research into the science of aging. "It seems to have a dramatic effect in worms," he added. "Whether it will have the same effect in other organisms will have to be established." The research is published in the journal, Science.

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